⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792859 | 0.76 | — | — | |
| SCHEMBL18334444 | 0.76 | HMGCR (0.50) | — | |
| SCHEMBL7662459 | 0.76 | HMGCR (0.50) | — | |
| SCHEMBL7605166 | 0.75 | HMGCR (0.50) | — | |
| SCHEMBL4086413 | 0.72 | HMGCR (0.46) | — | |
| SCHEMBL3713463 | 0.72 | CYP2C19 (0.50) | — | |
| SCHEMBL416276 | 0.72 | CYP2C19 (0.50) | — | |
| SCHEMBL28943927 | 0.72 | — | — | |
| SCHEMBL9781854 | 0.72 | ALDH1A1 (0.46) | — | |
| SCHEMBL4628158 | 0.72 | CYP2C19 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718637-B2 | Prodrugs of 4′-C-substituted-2-halo-2′- deoxyadenosine nucleosides and methods of making and using the same | GILEAD SCIENCES, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| EP-4121437-A1 | PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME | GILEAD SCIENCES, INC. (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-115605493-A | Prodrugs of4'-C-substituted-2-halo-2' -deoxyadenosine nucleosides and methods of making and using the same | 吉利德科学公司（US） | 2023-01-13 | — | — | CN | disclosed |
| US-20220363708-A1 | PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME | GILEAD SCIENCES, INC. | 2022-11-17 | — | — | US | disclosed |
| WO-2021188959-A1 | PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME | GILEAD SCIENCES, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| EP-1251142-B1 | Use of copolymers based on acrylamidoalkylenesulphonic acid as thickener in compositions containing an organic solvent | CLARIANT PRODUKTE DEUTSCHLAND (DE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1251142-A1 | Use of copolymers based on acrylamidoalkylenesulphonic acid as thickener in compositions containing an organic solvent | Clariant GmbH (DE) | 2002-10-23 | — | — | EP | disclosed |