SCHEMBL4622382

SCHEMBL4622382

NC(=O)CC[C@H](NC(=O)C1c2ccccc2-c2ccccc21)C(=O)OCc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MME P08473 1/20 0.43
ECE1 P42892 1/20 0.43
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
MCHR1 Q99705 1/20 0.41
POLB P06746 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
NCOR2 Q9Y618 1/20 0.40
TDO2 P48775 1/20 0.39
PTPN1 P18031 1/20 0.39
ACE P12821 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28792081 0.86 HDAC1 (0.54) IDO1SMN1; SMN2HDAC1HDAC2PTPN1
SCHEMBL5032097 0.85 HDAC1 (0.47) IDO1ECE1HDAC1HDAC2MCHR1
SCHEMBL5032091 0.85 HDAC1 (0.47) IDO1ECE1HDAC1HDAC2MCHR1
SCHEMBL2243802 0.84 KMT2A (0.53) MCHR1POLBHDAC3HDAC4HDAC7
SCHEMBL29682481 0.80 MME (0.56) SMN1; SMN2MMEECE1
SCHEMBL28993693 0.80 MME (0.56) SMN1; SMN2MMEECE1
SCHEMBL4919342 0.80 MME (0.56) SMN1; SMN2MMEECE1
SCHEMBL4919347 0.80 MME (0.56) SMN1; SMN2MMEECE1
SCHEMBL24978636 0.79 TACR1 (0.56) SMN1; SMN2MMEECE1POLBKMT2A
SCHEMBL7046063 0.79 TACR1 (0.56) SMN1; SMN2MMEECE1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1902014-A2 GLUTAMATE AGGRECANASE INHIBITORS Wyeth (US) 2008-03-26 EP claimed
WO-2007008994-A2 GLUTAMATE AGGRECANASE INHIBITORS WYETH (US) 2007-01-18 WO claimed