Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620335 | 0.92 | HPGD (0.73) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL70433 | 0.89 | HPGD (0.69) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL23675251 | 0.87 | HPGD (0.71) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8658563 | 0.85 | HPGD (0.68) | HPGDALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19543 | 0.81 | CA1 (0.64) | HPGDALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL17559469 | 0.79 | HPGD (0.61) | HPGDALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL64495 | 0.79 | HPGD (0.78) | HPGDALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL17559372 | 0.79 | HPGD (0.61) | HPGDALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL17559346 | 0.79 | HPGD (0.61) | HPGDALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL28355937 | 0.78 | EPHX1 (0.54) | HPGDKMT2AMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883636-A1 | SUBSTITUTED PIPERIDINE ANTAGONIST OF HI RECEPTOR TO BE USED FOR THE TREATMENT OF RHINITIS | GLAXO GROUP LIMITED (GB) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006125665-A1 | SUBSTITUTED PIPERIDINE ANTAGONIST OF HI RECEPTOR TO BE USED FOR THE TREATMENT OF RHINITIS | GLAXO GROUP LIMITED (GB) | 2006-11-30 | — | — | WO | disclosed |