Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053114 | 0.98 | NPSR1 (0.40) | NPSR1CYP2C19TSHRMAPTHSD11B1 | |
| SCHEMBL3670181 | 0.93 | CYP2C19 (0.41) | NPSR1CYP2C19TSHRMAPTCYP3A4 | |
| SCHEMBL13009913 | 0.79 | CYP2C19 (0.41) | NPSR1CYP2C19TSHRMAPTCYP3A4 | |
| SCHEMBL4554424 | 0.79 | CYP2C19 (0.41) | NPSR1CYP2C19TSHRMAPTCYP3A4 | |
| SCHEMBL12083404 | 0.76 | NPSR1 (0.40) | NPSR1CYP2C19TSHRMAPTHSD11B1 | |
| SCHEMBL9583269 | 0.75 | NPSR1 (0.39) | NPSR1CYP2C19TSHRMAPTHSD11B1 | |
| SCHEMBL30153499 | 0.75 | NPSR1 (0.39) | NPSR1CYP2C19TSHRMAPTHSD11B1 | |
| SCHEMBL28078638 | 0.75 | AKR1C1 (0.32) | CYP2C19 | |
| SCHEMBL7550154 | 0.74 | NPSR1 (0.41) | NPSR1CYP2C19TSHRMAPTHSD11B1 | |
| SCHEMBL12083349 | 0.74 | NPSR1 (0.41) | NPSR1CYP2C19TSHRMAPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1793817-A4 | METHODS OF TREATING A DISORDER | ELIXIR PHARMACEUTICALS INC (US) | 2008-04-02 | — | — | EP | disclosed |
| EP-1793817-A2 | METHODS OF TREATING A DISORDER | Elixir Pharmaceuticals, Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006031894-A2 | METHODS OF TREATING A DISORDER | ELIXIR PHARMACEUTICALS, INC. (US) | 2006-03-23 | — | — | WO | disclosed |