SCHEMBL4622636

SCHEMBL4622636

CC1=Cc2c(C(C)C)cc(C(C)C)cc2C1CCC1C(C)=Cc2c(C(C)C)cc(C(C)C)cc21

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.34
GABRB2 P47870 1/20 0.34
FABP3 P05413 2/20 0.33
FABP4 P15090 2/20 0.33
FABP5 Q01469 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8678755 0.87 GABRA1 (0.33) GABRA1GABRB2FABP3FABP4FABP5
SCHEMBL7035176 0.86 GABRA1 (0.32) GABRA1GABRB2FABP3FABP4FABP5
SCHEMBL16353479 0.82
SCHEMBL1452721 0.82
SCHEMBL6058735 0.81
SCHEMBL4622600 0.81 GABRA1 (0.33) GABRA1GABRB2FABP3FABP4FABP5
SCHEMBL6058536 0.79
SCHEMBL7031598 0.78 GABRA1 (0.36) GABRA1GABRB2
SCHEMBL5860017 0.78 GABRA1 (0.35) GABRA1GABRB2FABP3FABP4FABP5
SCHEMBL8506274 0.78 GABRA1 (0.35) GABRA1GABRB2FABP3FABP4FABP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1053263-B1 CATALYST SYSTEM BASELL POLYOLEFINE GMBH (DE) 2003-10-01 EP claimed
EP-0545303-B1 Process for preparing high molecular weight polyolefins HOECHST AG (DE) 1997-10-01 EP claimed
EP-1219657-B1 POLYARYLENE AND METHOD FOR PRODUCTION THEREOF JAPAN SCIENCE & TECH AGENCY (JP) 2008-03-19 EP disclosed
EP-0770587-B1 Process for the production of an indene compound and its use for the production of a metallocene catalyst BASELL POLYOLEFINE GMBH (DE) 2006-03-22 EP disclosed
US-6620953-B1 Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts BASSELL POLYOLEFINE GMBH (DE) 2003-09-16 US disclosed
EP-1133504-B1 METHOD FOR PRODUCING MONOARYLOXY-ANSA-METALLOCENES BASELL POLYOLEFINE GMBH (DE) 2003-03-12 EP disclosed
EP-1219657-A1 POLYARYLENE AND METHOD FOR PRODUCTION THEREOF Japan Science and Technology Corporation (JP) 2002-07-03 EP disclosed
EP-0545304-B1 Process for the preparation of substituted indenes and their use as ligands for metallocene catalysts BASELL POLYOLEFINE GMBH (DE) 2002-06-19 EP disclosed
US-20020052446-A1 Composition based on monofluorometal complexes BAYER AKTIENGESELLSCHAFT (DE) 2002-05-02 US disclosed
US-6051522-A Catalyst which can be used for the preparation of olefins during polymerization TARGOR GMBH (DE) 2000-04-18 US disclosed
US-5965678-A Catalyst system based on monoazadiene metal complexes BAYER AG (DE) 1999-10-12 US disclosed
US-5929264-A Process for the preparation of substituted indenes and their use as ligand systems for metallocene catalysts TARGOR GMBH (DE) 1999-07-27 US disclosed
US-5852142-A Process for the preparation of an olefin polymer TARGOR GMBH (DE) 1998-12-22 US disclosed
US-5840948-A Process for the preparation of substituted indenes and their use as ligand systems for metallocene catalysts TARGOR GMBH (DE) 1998-11-24 US disclosed
EP-0545303-B1 Process for preparing high molecular weight polyolefins HOECHST AG (DE) 1997-10-01 EP disclosed
EP-0770587-A2 Process for the production of an indene compound and its use for the production of a metallocene catalyst HOECHST AKTIENGESELLSCHAFT (DE) 1997-05-02 EP disclosed
US-5374752-A Catalyst system containing metallocene HOECHST AKTIENGESELLSCHAFT (DE) 1994-12-20 US disclosed
US-5328969-A Cocatalyst of an aluminoxane and metallocene HOECHST AKTIENGELLSCHAFT (DE) 1994-07-12 US disclosed
EP-0545303-A1 Process for preparing high molecular weight polyolefins HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-09 EP disclosed
EP-0545304-A1 Process for the preparation of substituted indenes and their use as ligands for metallocene catalysts HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-09 EP disclosed