Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluticasone Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 14/20 | 0.94 |
| ▸ | PGR | P06401 | 5/20 | 0.94 |
| ▸ | AR | P10275 | 5/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.94 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.94 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.94 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.94 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.73 |
| ▸ | CNR1 | P21554 | 1/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluticasone Propionate SCHEMBL896669 | 0.98 | NR3C1 (0.95) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL4283 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL191134 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL15325049 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL4111260 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL191133 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL5482829 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL13993454 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL14339613 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 | |
| Fluticasone Propionate SCHEMBL15944858 | 0.97 | NR3C1 (1.00) | NR3C1PGRARCYP3A4ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143930-B8 | PHARMACEUTICAL FORMULATION OF FLUTICASONE PROPIONATE | GLAXO GROUP LTD (GB) | 2008-03-19 | — | — | EP | disclosed |
| US-7220403-B2 | Pharmaceutical formulation of fluticasone propionate | GLAXO GROUP LIMITED (GB) | 2007-05-22 | — | — | US | disclosed |
| EP-1143930-B1 | PHARMACEUTICAL FORMULATION OF FLUTICASONE PROPIONATE | GLAXO GROUP LTD (GB) | 2006-10-25 | — | — | EP | disclosed |
| US-20040157815-A1 | Pharmaceutical formulation of fluticasone propionate | SMITHKLINE BEECHAM CORPORATION | 2004-08-12 | — | — | US | disclosed |
| US-20040037783-A1 | Pharmaceutical formulation of fluticasone propionate | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-26 | — | — | US | disclosed |
| US-6630129-B2 | Completely dissolved in hydrofluoroalkane propellant; aerosol; 1,1,1,2-tetrafluoroethane; ethanol as solubilizing agent; administration by inhalation | SMITHKLINE BEECHAM CORPORATION | 2003-10-07 | — | — | US | disclosed |
| US-20030086876-A1 | Pharmaceutical formulation of fluticasone propionate | GLAXO GROUP LIMITED (GB) | 2003-05-08 | — | — | US | disclosed |
| US-6479035-B1 | HYDROFLUOROALKANE PROPELLANT | SMITHKLINE BEECHAM CORPORATION | 2002-11-12 | — | — | US | disclosed |
| EP-1143930-A3 | PHARMACEUTICAL FORMULATION OF FLUTICASONE PROPIONATE | GLAXO GROUP LIMITED (GB) | 2002-09-11 | — | — | EP | disclosed |
| EP-1143930-A2 | PHARMACEUTICAL FORMULATION OF FLUTICASONE PROPIONATE | GLAXO GROUP LIMITED (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001019342-A2 | PHARMACEUTICAL FORMULATION OF FLUTICASONE PROPIONATE | GLAXO GROUP LIMITED (GB) | 2001-03-22 | — | — | WO | disclosed |