Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 12/20 | 0.72 |
| ▸ | USP7 | Q93009 | 4/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30521818 | 0.84 | FYN (1.00) | FYNUSP7MAP4K4CHEK2CHEK1 | |
| SCHEMBL4620276 | 0.84 | FYN (1.00) | FYNUSP7MAP4K4CHEK2CHEK1 | |
| SCHEMBL4620369 | 0.80 | USP7 (0.73) | FYNUSP7MAP4K4CHEK2MINK1 | |
| SCHEMBL5379608 | 0.80 | ESR1 (0.55) | — | |
| SCHEMBL2226239 | 0.78 | MAP4K4 (0.65) | FYNMAP4K4CHEK2CHEK1MINK1 | |
| SCHEMBL27885069 | 0.78 | MAP4K4 (0.47) | FYNUSP7MAP4K4CHEK2CHEK1 | |
| SCHEMBL4025534 | 0.76 | MAP4K4 (0.57) | MAP4K4 | |
| SCHEMBL2559138 | 0.75 | ATR (0.46) | FYNMAP4K4CHEK2 | |
| SCHEMBL2554637 | 0.74 | ADORA1 (0.46) | FYNMAP4K4CHEK2 | |
| SCHEMBL4620617 | 0.74 | USP7 (0.69) | FYNUSP7MAP4K4CHEK2MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |