Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 5/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.59 |
| ▸ | FYN | P06241 | 9/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621735 | 0.81 | KCNH2 (0.59) | MAP4K4FYNCHEK2MINK1TGFBR1 | |
| SCHEMBL4824826 | 0.76 | KIF11 (0.71) | KCNH2 | |
| SCHEMBL4620369 | 0.75 | USP7 (0.73) | USP7MAP4K4FYNCHEK2MINK1 | |
| SCHEMBL2227983 | 0.74 | MAP4K4 (0.66) | USP7MAP4K4FYNCHEK2MINK1 | |
| SCHEMBL4623629 | 0.74 | FYN (0.72) | USP7MAP4K4FYNCHEK2MINK1 | |
| SCHEMBL2224558 | 0.73 | MAP4K4 (0.57) | USP7MAP4K4MINK1KCNH2PIK3CA | |
| SCHEMBL18613241 | 0.72 | FYN (1.00) | USP7MAP4K4FYNCHEK2 | |
| SCHEMBL18613514 | 0.72 | FYN (1.00) | USP7FYNCHEK2TGFBR1 | |
| SCHEMBL18066814 | 0.72 | USP7 (1.00) | USP7 | |
| SCHEMBL2228665 | 0.72 | USP7 (0.71) | USP7MAP4K4FYNCHEK2MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |