Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.86 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10192710 | 0.93 | HDAC8 (0.85) | HDAC8GRM5ALDH1A1TSHRNPC1 | |
| SCHEMBL443998 | 0.93 | HDAC8 (1.00) | HDAC8GRM5ALDH1A1TSHRMEN1 | |
| SCHEMBL461269 | 0.79 | HDAC8 (0.85) | HDAC8TSHRMAPK1MEN1KMT2A | |
| SCHEMBL445401 | 0.76 | HDAC8 (1.00) | HDAC8GRM5NPC1RAB9AMEN1 | |
| SCHEMBL443999 | 0.76 | HDAC8 (0.52) | HDAC8GRM5ALDH1A1TSHRNPC1 | |
| SCHEMBL2468483 | 0.75 | NPC1 (0.71) | GRM5ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL444288 | 0.75 | HDAC8 (1.00) | HDAC8NPC1RAB9AMEN1KMT2A | |
| SCHEMBL444916 | 0.74 | HDAC8 (1.00) | HDAC8ALDH1A1MEN1KMT2A | |
| SCHEMBL3619472 | 0.73 | HDAC8 (0.49) | HDAC8NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10247271 | 0.73 | HDAC8 (0.68) | HDAC8GRM5ALDH1A1TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613775-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | claimed |
| WO-2012031993-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | claimed |