Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.85 |
| ▸ | PYGL | P06737 | 2/20 | 0.50 |
| ▸ | PYGM | P11217 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441671 | 0.92 | HDAC8 (1.00) | HDAC8PYGLPYGMTAS1R3TAS1R2 | |
| SCHEMBL445525 | 0.81 | HDAC8 (1.00) | HDAC8HDAC1HDAC6 | |
| SCHEMBL462374 | 0.79 | HDAC8 (0.86) | HDAC8TSHRMEN1MAPK1KMT2A | |
| SCHEMBL444288 | 0.77 | HDAC8 (1.00) | HDAC8MEN1KMT2AHDAC1HDAC6 | |
| SCHEMBL649195 | 0.73 | HDAC8 (0.60) | HDAC8EPHX2MAPK1 | |
| SCHEMBL441672 | 0.73 | HDAC8 (0.48) | HDAC8PYGLPYGMTSHRTAS1R3 | |
| SCHEMBL30372190 | 0.72 | KDM4E (0.54) | HDAC8KDM4EMAPTSRD5A2 | |
| SCHEMBL2104667 | 0.72 | HDAC8 (0.55) | HDAC8PYGLPYGMTAS1R3EPHX2 | |
| SCHEMBL5188022 | 0.71 | HDAC8 (0.62) | HDAC8PYGLPYGMEPHX2MAPT | |
| SCHEMBL444916 | 0.71 | HDAC8 (1.00) | HDAC8TAS1R3TAS1R2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613775-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | claimed |
| WO-2012031993-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | claimed |