Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.64 |
| ▸ | MMP8 | P22894 | 1/20 | 0.64 |
| ▸ | MMP12 | P39900 | 1/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249511 | 0.94 | ADAMTS5 (0.69) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2247372 | 0.91 | ADAMTS5 (0.64) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2247404 | 0.91 | ADAMTS5 (0.71) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2244952 | 0.90 | ADAMTS5 (0.70) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2254224 | 0.86 | ADAMTS5 (0.60) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2243910 | 0.86 | ADAMTS5 (0.56) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2247930 | 0.86 | ADAMTS5 (0.62) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL5653579 | 0.85 | ADAMTS5 (0.84) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2247435 | 0.84 | ADAMTS5 (0.60) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2249785 | 0.84 | ADAMTS5 (0.58) | ADAMTS5MMP2MMP8MMP12ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | claimed |