Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840910 | 0.89 | HPGD (0.44) | HPGDGPR119EPHX1 | |
| SCHEMBL24161826 | 0.73 | NR1H2 (0.51) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL14697592 | 0.72 | NR1H2 (0.50) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL18239343 | 0.70 | NR1H2 (0.49) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL29208875 | 0.70 | NR1H2 (0.49) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL22695207 | 0.70 | NR1H2 (0.49) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL3650512 | 0.70 | NR1H2 (0.49) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL22689240 | 0.70 | NR1H2 (0.49) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL34474589 | 0.70 | NR1H2 (0.48) | DDB1CRBNNR1H2MEN1ALDH1A1 | |
| SCHEMBL13086399 | 0.70 | GPR119 (0.54) | HPGDGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904479-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | Sanofi-Aventis (FR) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006926-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2007-01-18 | — | — | WO | disclosed |