Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27681435 | 0.88 | SLC6A2 (0.43) | SLC6A2SLC6A4LMNAALDH1A1KMT2A | |
| SCHEMBL27661851 | 0.88 | SLC6A2 (0.43) | SLC6A2OPRM1RAB9A | |
| SCHEMBL27655992 | 0.88 | LMNA (0.39) | OPRM1CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL27675975 | 0.84 | NPSR1 (0.40) | OPRM1CHRM3CHRM2CHRM1LMNA | |
| SCHEMBL27681429 | 0.84 | SLC6A2 (0.39) | SLC6A2SLC6A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3961302 | 0.82 | KMT2A (0.43) | SLC6A2SLC6A4OPRM1SLC6A3LMNA | |
| SCHEMBL27662478 | 0.82 | SLC6A2 (0.49) | SLC6A2SLC6A4 | |
| SCHEMBL27656144 | 0.81 | DPP7 (0.46) | ALDH1A1MAPTPOLBSMN1; SMN2RAB9A | |
| SCHEMBL27656082 | 0.81 | LMNA (0.41) | SLC6A2SLC6A4SLC6A3CHRM3CHRM2 | |
| SCHEMBL3954346 | 0.79 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687288-B1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| CN-1972920-A | Arylalkyl piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms | WYETH CORP (US) | 2007-05-30 | — | — | CN | disclosed |
| CN-1894226-A | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use | WYETH CORP (US) | 2007-01-10 | — | — | CN | disclosed |