Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2942339 | 0.94 | PTGDR2 (0.52) | MAPTPTGDR2SMN1; SMN2LMNAHTT | |
| SCHEMBL2944820 | 0.85 | PTGDR2 (0.52) | MAPTPTGDR2SMN1; SMN2LMNAHTT | |
| SCHEMBL2944566 | 0.83 | SMN1; SMN2 (0.49) | MAPTPTGDR2SMN1; SMN2LMNAHTT | |
| SCHEMBL15134824 | 0.83 | SMN1; SMN2 (0.80) | MAPTSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL4628496 | 0.82 | MAPT (0.79) | MAPTPTGDR2TSHRTDP1PTGDR | |
| SCHEMBL15134842 | 0.82 | SMN1; SMN2 (0.83) | MAPTSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL2938776 | 0.81 | PTGDR2 (0.48) | MAPTPTGDR2SMN1; SMN2LMNAHTT | |
| SCHEMBL4626978 | 0.76 | MAPT (0.65) | MAPTPTGDR2LMNATSHRTDP1 | |
| SCHEMBL4626233 | 0.76 | MAPT (0.68) | MAPTPTGDR2TSHRTDP1PTGDR | |
| SCHEMBL2949145 | 0.76 | SMN1; SMN2 (0.57) | MAPTPTGDR2SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891029-A1 | ORGANIC COMPOUNDS FOR THE TREATMENT OF IMFLAMMATORY OR ALLERIC CONDITIONS | Novartis AG (CH) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006125596-A1 | ORGANIC COMPOUNDS FOR THE TREATMENT OF IMFLAMMATORY OR ALLERIC CONDITIONS | NOVARTIS AG (CH) | 2006-11-30 | — | — | WO | disclosed |