Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 7/20 | 0.75 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.70 |
| ▸ | TPH1 | P17752 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629035 | 0.86 | SCN2A (0.83) | SCN2ASCN5ANPC1RAB9AMEN1 | |
| SCHEMBL4628365 | 0.86 | SCN2A (1.00) | SCN2ASCN5ATPH1MEN1KMT2A | |
| SCHEMBL4628735 | 0.85 | SCN2A (0.72) | SCN2ASCN5ATPH1NPC1RAB9A | |
| SCHEMBL4628688 | 0.83 | SCN5A (1.00) | SCN2ASCN5ASCNN1A | |
| SCHEMBL4628794 | 0.82 | SCN2A (0.74) | SCN2ASCN5ATPH1NPC1RAB9A | |
| SCHEMBL4628993 | 0.81 | SCN2A (0.79) | SCN2ASCN5ANPC1RAB9AMEN1 | |
| SCHEMBL18690745 | 0.78 | SCN2A (0.63) | SCN2ATPH1NPC1MALT1GRIN2B | |
| SCHEMBL18690743 | 0.78 | SCN2A (0.63) | SCN2ATPH1NPC1MALT1GRIN2B | |
| SCHEMBL4628518 | 0.77 | SCN2A (0.60) | SCN2ASCN5ATPH1NPC1RAB9A | |
| SCHEMBL28555938 | 0.74 | CES2 (0.65) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918272-A1 | Pharmaceutically active compounds and methods of use | Wyeth a Corporation of the State of Delaware (US) | 2008-05-07 | — | — | EP | disclosed |
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | US | disclosed |
| US-7041702-B1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | GBA1, CTSA, GAA | SCN2A 1613/4885SCN5A 1196/4885TPH1 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.