Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | GHSR | Q92847 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15958829 | 0.80 | ALDH1A1 (0.64) | ALDH1A1GHSRPOLBKMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL1314648 | 0.79 | ALDH1A1 (0.63) | ALDH1A1GHSRPOLBKMT2AL3MBTL1 | |
| SCHEMBL6184020 | 0.76 | IKBKB (0.61) | PKMMAPT | |
| SCHEMBL1314374 | 0.75 | ALDH1A1 (0.63) | ALDH1A1GHSRPOLBKMT2AL3MBTL1 | |
| SCHEMBL1314372 | 0.75 | ALDH1A1 (0.66) | ALDH1A1POLBKMT2AL3MBTL1MMP8 | |
| SCHEMBL14055914 | 0.73 | ALDH1A1 (0.59) | ALDH1A1POLBKMT2AL3MBTL1MMP8 | |
| SCHEMBL1618671 | 0.73 | ALDH1A1 (0.52) | ALDH1A1POLBKMT2AL3MBTL1MMP8 | |
| SCHEMBL15462054 | 0.73 | ALDH1A1 (0.53) | ALDH1A1GHSRPOLBKMT2AL3MBTL1 | |
| SCHEMBL1619096 | 0.73 | HDAC1 (0.56) | ALDH1A1POLBKMT2AL3MBTL1MMP8 | |
| SCHEMBL3055723 | 0.72 | KDM4E (0.60) | ALDH1A1POLBL3MBTL1MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |