Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | PRKACA | P17612 | 5/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.46 |
| ▸ | GSK3A | P49840 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.46 |
| ▸ | AKT1 | P31749 | 3/20 | 0.46 |
| ▸ | AKT2 | P31751 | 3/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.46 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4912602 | 0.81 | PIK3CD (0.49) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL14066911 | 0.79 | PIK3CD (0.57) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL4903209 | 0.78 | ROCK2 (0.48) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL4629366 | 0.77 | PIK3CD (0.46) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL1230005 | 0.75 | CDK7 (0.47) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL4629359 | 0.73 | AURKB (0.67) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL4912933 | 0.73 | CLK4 (0.48) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL1229663 | 0.72 | JAK2 (0.49) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL14066916 | 0.69 | GSK3A (0.44) | ROCK1PRKACARPS6KA3PRKAA1AURKB | |
| SCHEMBL4629381 | 0.69 | MAPKAPK2 (0.51) | ROCK1AURKBGSK3AGSK3BCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234348-A1 | 3-Oxoindazolesquaric Acid Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | claimed |
| US-20080234348-A1 | 3-Oxoindazolesquaric Acid Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
| EP-1917249-A1 | 3-OXO-INDAZOLE-SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022858-A1 | 3-OXO-INDAZOLE-SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234348-A1 | 3-Oxoindazolesquaric Acid Derivatives | CHEK2, CHEK1, SGK2 | ROCK1 944/4885PRKACA 1549/4885RPS6KA3 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.