Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.47 |
| ▸ | DNM2 | P50570 | 11/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.39 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19454317 | 0.89 | TLR8 (0.42) | TLR8DNM2HCAR3ALDH1A1LMNA | |
| SCHEMBL3193118 | 0.81 | TLR8 (0.47) | TLR8DNM2HCAR3KCNH3LATS1 | |
| SCHEMBL12263362 | 0.81 | KDR (0.45) | TLR8ALDH1A1MAPK1KCNH3 | |
| SCHEMBL12497287 | 0.80 | GRM5 (0.35) | TLR8HCAR3LMNA | |
| SCHEMBL24672584 | 0.80 | TLR8 (0.58) | TLR8DNM2ALDH1A1LMNATP53 | |
| SCHEMBL4628006 | 0.80 | HRH1 (0.50) | TLR8DNM2HCAR3 | |
| SCHEMBL3186741 | 0.80 | TLR8 (0.46) | TLR8DNM2HCAR3 | |
| SCHEMBL12263364 | 0.80 | TP53 (0.49) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL15286462 | 0.79 | PIM2 (0.39) | TLR8ALDH1A1SMN1; SMN2 | |
| SCHEMBL18462430 | 0.79 | DNM2 (0.42) | TLR8DNM2HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1734820-A4 | IMIDAZOPYRAZINES, IMIDAZOPYRIDINES, AND IMIDAZOPYRIMIDINES AS CRF1 RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1734820-A2 | IMIDAZOPYRAZINES, IMIDAZOPYRIDINES, AND IMIDAZOPYRIMIDINES AS CRF1 RECEPTOR LIGANDS | Neurogen Corporation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005115399-A2 | IMIDAZOPYRAZINES, IMIDAZOPYRIDINES, ANS IMIDAZOPYRIMIDINES AS CRF1 RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |