Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.53 |
| ▸ | OXTR | P30559 | 1/20 | 0.53 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628545 | 0.93 | STAT3 (0.67) | POLBHSD17B10STAT3SCN2AHSD11B1 | |
| SCHEMBL4627586 | 0.80 | SCN2A (0.67) | SCN2AAVPR2AVPR1AMAPTSMN1; SMN2 | |
| SCHEMBL4628474 | 0.80 | SCN2A (0.86) | POLBSCN2AAVPR2AVPR1ASMN1; SMN2 | |
| SCHEMBL4627492 | 0.77 | SCN2A (0.60) | SCN2AAVPR2AVPR1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4628693 | 0.74 | ALDH1A1 (0.58) | POLBHSD17B10SCN2AMAPTSMN1; SMN2 | |
| SCHEMBL4629002 | 0.74 | TSHR (0.67) | POLBSCN2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31700840 | 0.74 | STAT3 (1.00) | POLBHSD17B10STAT3AVPR2OXTR | |
| SCHEMBL24499976 | 0.73 | POLB (0.80) | POLBHSD17B10STAT3AVPR2OXTR | |
| SCHEMBL29597092 | 0.73 | POLB (0.80) | POLBHSD17B10STAT3AVPR2OXTR | |
| SCHEMBL4628733 | 0.72 | SCN2A (0.77) | POLBSCN2AAVPR2AVPR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918272-A1 | Pharmaceutically active compounds and methods of use | Wyeth a Corporation of the State of Delaware (US) | 2008-05-07 | — | — | EP | claimed |
| US-7041702-B1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | claimed |
| EP-1918272-A1 | Pharmaceutically active compounds and methods of use | Wyeth a Corporation of the State of Delaware (US) | 2008-05-07 | — | — | EP | disclosed |
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | US | disclosed |
| US-7041702-B1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | GBA1, CTSA, GAA | POLB 2690/4885HSD17B10 1498/4885STAT3 4821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.