Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.56 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.53 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pronetalol SCHEMBL9666931 | 0.86 | TSHR (1.00) | CYP2D6MEN1CYP1A2TSHRKMT2A | |
| Pronetalol SCHEMBL31108442 | 0.86 | TSHR (1.00) | CYP2D6MEN1CYP1A2TSHRKMT2A | |
| Pronetalol SCHEMBL78996 | 0.86 | TSHR (1.00) | CYP2D6MEN1CYP1A2TSHRKMT2A | |
| Pronetalol SCHEMBL3203560 | 0.84 | TSHR (0.97) | CYP2D6MEN1CYP1A2TSHRKMT2A | |
| Pronetalol SCHEMBL10783519 | 0.84 | TSHR (0.97) | CYP2D6MEN1CYP1A2TSHRKMT2A | |
| Pronetalol SCHEMBL14973465 | 0.83 | TSHR (0.94) | CYP2D6MEN1CYP1A2TSHRKMT2A | |
| SCHEMBL12186584 | 0.80 | KDM4E (0.57) | ADRB2AOC3ADRB1ADRB3 | |
| SCHEMBL12186577 | 0.80 | KDM4E (0.57) | ADRB2AOC3ADRB1ADRB3 | |
| SCHEMBL12832485 | 0.79 | CYP2D6 (0.71) | CYP2D6MEN1CYP1A2TSHRKMT2A | |
| SCHEMBL2894556 | 0.78 | CYP2D6 (0.59) | CYP2D6MEN1CYP1A2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306162-A1 | Treatment of Inflammatory Disorders and Pain | SOSEI R&D LTD. (GB) | 2008-12-11 | — | — | US | disclosed |
| EP-1896393-A1 | THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN | Sosei R&D Ltd. (GB) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007003896-A1 | THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN | SOSEI R & D LTD. (GB) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306162-A1 | Treatment of Inflammatory Disorders and Pain | HRH3, OPRL1, HRH2 | CYP2D6 2783/4885MEN1 4390/4885CYP1A2 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.