Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389292 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL2389294 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL2390289 | 0.76 | ALDH1A1 (0.38) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL2390292 | 0.76 | ALDH1A1 (0.38) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL2387665 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL4628023 | 0.74 | EPHX2 (0.40) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL4627801 | 0.72 | TRPV1 (0.39) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL4628938 | 0.71 | EPHX2 (0.38) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL2390059 | 0.70 | CYP1A2 (0.40) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL4627639 | 0.70 | CYP1A2 (0.39) | SMN1; SMN2LMNAPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871749-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006108591-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | NOVARTIS AG (CH) | 2006-10-19 | — | — | WO | disclosed |