Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720112 | 0.90 | KDM4E (0.45) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL690539 | 0.87 | HTR2C (0.46) | SMN1; SMN2KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL1206723 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2KMT2ANPC1RAB9AHTR2C | |
| SCHEMBL4629722 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL4707711 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL31085865 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2KMT2ANPC1RAB9AHTR2C | |
| SCHEMBL29260212 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2KMT2ANPC1RAB9AHTR2C | |
| SCHEMBL5198237 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL28636570 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2ANPC1RAB9AHTR2C | |
| SCHEMBL519379 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2AKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917256-A2 | SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020261-A2 | SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-22 | — | — | WO | disclosed |