Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 19/20 | 0.48 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628178 | 0.91 | KIF11 (0.52) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4629024 | 0.90 | KIF11 (0.49) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4628256 | 0.83 | KIF11 (0.49) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4629070 | 0.78 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5751482 | 0.77 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4965053 | 0.76 | KIF11 (0.43) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4965354 | 0.76 | KIF11 (0.44) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4366741 | 0.75 | KIF11 (0.54) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4364319 | 0.75 | KIF11 (0.58) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3962257 | 0.75 | KIF11 (0.65) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620092-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-04-16 | — | — | EP | claimed |
| EP-1620092-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004100873-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-11-25 | — | — | WO | claimed |