Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | MAOA | P21397 | 8/20 | 0.56 |
| ▸ | MAOB | P27338 | 8/20 | 0.56 |
| ▸ | PRF1 | P14222 | 1/20 | 0.51 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PPIB | P23284 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853706 | 0.91 | MAPT (0.58) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL26767260 | 0.91 | MAPT (0.58) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL30080967 | 0.85 | KDM4E (0.63) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL2315303 | 0.85 | KDM4E (0.63) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL26767982 | 0.85 | PRF1 (0.52) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL25386546 | 0.84 | KDM4E (0.58) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL31442244 | 0.84 | KDM4E (0.58) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL26779018 | 0.84 | MAPT (0.65) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL26767992 | 0.82 | PRF1 (0.52) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL6661823 | 0.82 | PRF1 (0.65) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633716-A4 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-03-26 | — | — | EP | disclosed |
| US-7129264-B2 | Biarylmethyl indolines and indoles as antithromboembolic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1633716-A2 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004094372-A2 | COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20040220206-A1 | Biarylmethyl indolines, indoles and tetrahydroquinolines, useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220206-A1 | Biarylmethyl indolines, indoles and tetrahydroquinolines, useful as serine protease inhibitors | TFPI, TFPI2, F2 | ALDH1A1 2594/4885SMN1; SMN2 4762/4885MAPT 3408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.