SCHEMBL6661823

SCHEMBL6661823

COc1ccc2c(c1)COC2=O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRF1 P14222 2/20 0.65
MAPT P10636 5/20 0.59
MAOA P21397 5/20 0.59
MAOB P27338 5/20 0.59
GAA P10253 3/20 0.59
KDM4E B2RXH2 2/20 0.59
ALDH1A1 P00352 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
HPGD P15428 2/20 0.59
NPC1 O15118 1/20 0.59
ALOX12 P18054 1/20 0.59
RAB9A P51151 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
CYP3A4 P08684 1/20 0.59
HSD17B10 Q99714 1/20 0.57
LMNA P02545 3/20 0.56
HTT P42858 2/20 0.53
MAPK1 P28482 1/20 0.53
METAP1 P53582 1/20 0.51
PPIA P62937 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29853706 0.92 MAPT (0.58) PRF1MAPTMAOAMAOBGAA
SCHEMBL26767260 0.92 MAPT (0.58) PRF1MAPTMAOAMAOBGAA
SCHEMBL2315303 0.86 KDM4E (0.63) PRF1MAPTMAOAMAOBGAA
SCHEMBL30080967 0.86 KDM4E (0.63) PRF1MAPTMAOAMAOBGAA
SCHEMBL25386546 0.85 KDM4E (0.58) PRF1MAPTMAOAMAOBGAA
SCHEMBL31442244 0.85 KDM4E (0.58) PRF1MAPTMAOAMAOBGAA
SCHEMBL26767992 0.83 PRF1 (0.52) PRF1MAPTMAOAMAOBGAA
SCHEMBL26767982 0.83 PRF1 (0.52) PRF1MAPTMAOAMAOBGAA
SCHEMBL1022250 0.83 CYP26A1 (0.50) PRF1MAPTGAAKDM4EALDH1A1
SCHEMBL4629150 0.82 ALDH1A1 (0.68) PRF1MAPTMAOAMAOBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024182747-A2 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-09-06 WO disclosed
EP-1490356-A1 (3Z)-3-(3-HYDRO-ISOBENZOFURAN-1-YLIDENE)-1,3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS Allergan, Inc. (US) 2004-12-29 EP disclosed
WO-2003084951-A1 (3Z) -3-(3-HYDRO-ISOBENZOFURAN-1-YLIDENE)-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS ALLERGAN, INC. (US) 2003-10-16 WO disclosed
US-4279823-A REACTION WITH A THALLIUM SALT THAN WITH A CARBON MONOXIDE IN THE PRESENCE OF A NOBLE METAL CATALYST IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 1981-07-21 US disclosed