Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.55 |
| ▸ | HTR3B | O95264 | 4/20 | 0.55 |
| ▸ | HTR3A | P46098 | 4/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | PLAU | P00749 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18543952 | 0.78 | CYP1A2 (0.51) | CYP1A2HPGDHSD17B10ALDH1A1PRKAG1 | |
| SCHEMBL18543955 | 0.78 | CYP1A2 (0.51) | CYP1A2HPGDHSD17B10ALDH1A1PRKAG1 | |
| SCHEMBL18543993 | 0.76 | CYP1A2 (0.49) | HTR3ACYP1A2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL128094 | 0.76 | ALDH1A1 (0.57) | HTR3ACYP1A2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL3684655 | 0.76 | ALDH1A1 (0.57) | CYP1A2HPGDHSD17B10ALDH1A1PRKAG1 | |
| SCHEMBL10156228 | 0.76 | ALDH1A1 (0.53) | HTR3ACYP1A2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL21192695 | 0.73 | CYP1A2 (0.46) | CYP1A2HPGDHSD17B10ALDH1A1PRKAG1 | |
| SCHEMBL21192693 | 0.73 | CYP1A2 (0.46) | CYP1A2HPGDHSD17B10ALDH1A1PRKAG1 | |
| SCHEMBL5658262 | 0.71 | ALDH1A1 (0.49) | CYP1A2HPGDHSD17B10ALDH1A1PRKAG1 | |
| SCHEMBL7119499 | 0.71 | ALDH1A1 (0.49) | CYP1A2HPGDHSD17B10ALDH1A1PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917244-A2 | HETARYL-SUBSTITUTED GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5-RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022964-A2 | HETARYL-SUBSTITUTED GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5-RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |