Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436540 | 0.83 | KLK7 (0.42) | KLK7POLBRECQL | |
| SCHEMBL435061 | 0.71 | POLB (0.34) | POLB | |
| SCHEMBL434788 | 0.71 | METAP2 (0.54) | KLK7 | |
| SCHEMBL27917950 | 0.67 | PARP1 (0.40) | POLB | |
| SCHEMBL10283925 | 0.67 | METAP2 (0.53) | — | |
| SCHEMBL436258 | 0.63 | POLB (0.34) | POLB | |
| SCHEMBL436027 | 0.62 | MAPT (0.35) | POLB | |
| SCHEMBL1925199 | 0.57 | MAPT (0.44) | KLK7POLBCA1CA2CA5A | |
| SCHEMBL1648256 | 0.55 | PLCG1 (0.41) | KLK7POLBCA1CA2CA5A | |
| SCHEMBL851838 | 0.55 | CA1 (0.61) | CA1CA2CA5ACA9RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | disclosed |