Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20284180 | 0.82 | CHRM4 (0.53) | HRH3GPR119CHRM4 | |
| SCHEMBL22581845 | 0.82 | GPR119 (0.52) | HRH3GPR119CHRM4DHFRCHIA | |
| SCHEMBL23172319 | 0.81 | PDE10A (0.48) | PDE10AKDM1A | |
| SCHEMBL15034209 | 0.81 | PDE10A (0.67) | PDE10AHRH3GPR119DHFR | |
| SCHEMBL24735175 | 0.81 | PDE10A (0.48) | PDE10AMAPK8KDM1A | |
| SCHEMBL2118784 | 0.81 | PDE10A (0.67) | PDE10ACHRM4 | |
| SCHEMBL30612346 | 0.81 | PDE10A (0.48) | PDE10AMAPK8KDM1A | |
| SCHEMBL1103853 | 0.81 | KDM4E (0.64) | HRH3GPR119CHRM4 | |
| SCHEMBL25081250 | 0.79 | BPTF (0.52) | HRH3GPR119CHRM4DHFRCHIA | |
| SCHEMBL1461357 | 0.79 | PDE10A (0.46) | PDE10AHRH3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |