Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.68 |
| ▸ | PIM1 | P11309 | 7/20 | 0.68 |
| ▸ | GSK3B | P49841 | 7/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.68 |
| ▸ | HPGDS | O60760 | 3/20 | 0.43 |
| ▸ | DHPS | P49366 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214861 | 0.88 | PIK3CD (0.65) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2214524 | 0.87 | PIK3CD (0.73) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL15387671 | 0.87 | PIK3CD (0.63) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL1119169 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL1251740 | 0.85 | PIK3CD (0.76) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2166255 | 0.84 | PIK3CD (0.72) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL1780911 | 0.84 | PIK3CD (0.69) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL458018 | 0.84 | PIK3CD (0.69) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL1781520 | 0.83 | PIK3CD (0.76) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL456388 | 0.83 | PIK3CD (0.70) | PIK3CDPIK3CBPIM1GSK3BPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613781-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |
| EP-2300437-A1 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES | Glaxo Group Limited (GB) | 2011-03-30 | — | — | EP | disclosed |