Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL299616 | 0.97 | DRD2 (0.61) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL513130 | 0.87 | DRD2 (0.66) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL293244 | 0.84 | DRD2 (0.68) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL2702236 | 0.79 | HTR2A (0.54) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL1243263 | 0.77 | DRD2 (0.53) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL4294507 | 0.75 | HTR2A (0.53) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL294382 | 0.74 | HTR2A (0.53) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL294686 | 0.73 | HTR2A (0.53) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| SCHEMBL293387 | 0.73 | DRD2 (0.53) | DRD2HTR1AHTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL510990 | 0.73 | HTR2A (0.51) | DRD2HTR1AHTR2AHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |