Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630306 | 0.97 | RXRA (0.43) | RXRANR1H2NR1H3THRBKDM4E | |
| SCHEMBL3473029 | 0.89 | RXRA (0.55) | RXRANR1H2NR1H3THRBKDM4E | |
| SCHEMBL3471207 | 0.87 | RXRA (0.54) | RXRANR1H2NR1H3THRBKDM4E | |
| SCHEMBL3470688 | 0.84 | RXRA (0.55) | RXRANR1H2NR1H3THRBSLC16A3 | |
| SCHEMBL3473838 | 0.81 | RXRA (0.54) | RXRANR1H2NR1H3DRD2DRD3 | |
| SCHEMBL3471047 | 0.81 | NR1H2 (0.57) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3472802 | 0.79 | NR1H2 (0.57) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3471305 | 0.79 | NR1H2 (0.56) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3472594 | 0.79 | NR1H2 (0.56) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL3474201 | 0.79 | NR1H2 (0.57) | RXRANR1H2NR1H3SLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |