Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172448 | 0.89 | GRM5 (0.80) | GRM5 | |
| SCHEMBL4990286 | 0.87 | GRM5 (0.77) | GRM5 | |
| SCHEMBL4630084 | 0.87 | GRM5 (1.00) | GRM5 | |
| SCHEMBL4630177 | 0.85 | GRM5 (1.00) | GRM5 | |
| SCHEMBL4630041 | 0.82 | GRM5 (0.75) | GRM5 | |
| SCHEMBL4630909 | 0.81 | GRM5 (0.81) | GRM5 | |
| SCHEMBL4630252 | 0.81 | GRM5 (0.72) | GRM5 | |
| SCHEMBL1020980 | 0.81 | GRM5 (0.67) | GRM5 | |
| SCHEMBL4629690 | 0.79 | GRM5 (0.74) | GRM5 | |
| SCHEMBL4629674 | 0.79 | GRM5 (0.70) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606277-B1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | EP | claimed |
| CN-100358889-C | Imidazol-4-yl-ethynyl-pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | CN | claimed |
| CN-1759111-A | Imidazol-4-yl-ethynyl-pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2006-04-12 | — | — | CN | claimed |
| US-20040229917-A1 | Imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-18 | — | — | US | claimed |
| EP-1606277-B8 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-10-15 | — | — | EP | disclosed |
| EP-1606277-B1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | EP | disclosed |
| CN-100358889-C | Imidazol-4-yl-ethynyl-pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | CN | disclosed |
| US-7153874-B2 | Imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-12-26 | — | — | US | disclosed |
| CN-1759111-A | Imidazol-4-yl-ethynyl-pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2006-04-12 | — | — | CN | disclosed |
| EP-1606277-A1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-21 | — | — | EP | disclosed |
| US-20040229917-A1 | Imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-18 | — | — | US | disclosed |
| WO-2004080998-A1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229917-A1 | Imidazole derivatives | GRIK4, GRIA4, GRIK5 | GRM5 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.