Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nemazoline SCHEMBL4630344 | 0.87 | HTR1B (0.49) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| Nemazoline SCHEMBL953212 | 0.85 | TAAR1 (0.53) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| Nemazoline SCHEMBL636058 | 0.84 | TAAR1 (0.54) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL953100 | 0.84 | TAAR1 (0.62) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL4629760 | 0.78 | TAAR1 (0.42) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL4629569 | 0.76 | RAD52 (0.61) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL954827 | 0.75 | TAAR1 (0.68) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL4986025 | 0.73 | TAAR1 (0.56) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL953553 | 0.71 | TAAR1 (0.60) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL952423 | 0.70 | TAAR1 (0.69) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |