Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 5/20 | 0.55 |
| ▸ | HTR1B | P28222 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954827 | 0.87 | TAAR1 (0.68) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL953972 | 0.84 | RAD52 (0.82) | RAD52TAAR1ADRA2BADRA2CCYP2D6 | |
| SCHEMBL21186239 | 0.76 | ALDH1A1 (0.52) | TAAR1LMNATSHRMAOAMAOB | |
| Nemazoline SCHEMBL4629757 | 0.76 | TAAR1 (0.50) | RAD52TAAR1ADRA2BADRA2CCYP2D6 | |
| SCHEMBL952423 | 0.76 | TAAR1 (0.69) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL4036373 | 0.75 | RAD52 (0.68) | RAD52TAAR1ADRA2BADRA2CCYP2D6 | |
| Nemazoline SCHEMBL4630344 | 0.75 | HTR1B (0.49) | TAAR1ADRA2BADRA2CCYP2D6ADRA2A | |
| SCHEMBL2869241 | 0.75 | HTR1D (0.69) | RAD52TAAR1ADRA2BADRA2CCYP2D6 | |
| Tolazoline SCHEMBL34961 | 0.75 | TAAR1 (1.00) | RAD52TAAR1ADRA2BADRA2CCYP2D6 | |
| SCHEMBL4629571 | 0.74 | TAAR1 (0.48) | RAD52TAAR1ADRA2BADRA2CCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |