Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465934 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL3612370 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL12468610 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL17674539 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL3511778 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL353851 | 0.76 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL367981 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL4259400 | 0.73 | L3MBTL1 (0.39) | SMN1; SMN2KMT2ANPC1RAB9ALMNA | |
| SCHEMBL2576612 | 0.73 | KMT2A (0.47) | SMN1; SMN2KMT2APDE5AKDM4ENPC1 | |
| SCHEMBL3607475 | 0.72 | PDE5A (0.70) | PDE5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1921074-A1 | THIAZOLE DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-05-14 | — | — | EP | disclosed |