⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2290828 | 0.80 | — | — | |
| SCHEMBL27984476 | 0.78 | — | — | |
| SCHEMBL9818476 | 0.78 | — | — | |
| SCHEMBL4645772 | 0.76 | TSHR (0.43) | — | |
| SCHEMBL28073925 | 0.75 | ALDH1A1 (0.42) | — | |
| SCHEMBL9753968 | 0.75 | TSHR (0.39) | — | |
| SCHEMBL9842007 | 0.74 | TSHR (0.48) | — | |
| SCHEMBL9238745 | 0.74 | TSHR (0.48) | — | |
| SCHEMBL3273725 | 0.74 | TSHR (0.48) | — | |
| SCHEMBL28182288 | 0.74 | TSHR (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787801-B2 | Protein kinase inhibitors, preparation method and medical use thereof | GAN & LEE PHARMACEUTICALS (CN) | 2023-10-17 | — | — | US | disclosed |
| CN-113956238-B | Protein kinase inhibitor and preparation method and medical application thereof | 甘李药业股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-3385262-B1 | 4-(3H-INDOL-5-YL)-N-(PYRIDIN-2-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS, PREPARATION METHOD AND MEDICAL USE THEREOF | GAN & LEE PHARMACEUTICALS (CN) | 2022-07-13 | — | — | EP | disclosed |
| CN-108290864-B | Protein kinase inhibitor and preparation method and medical application thereof | 甘李药业股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-113956238-A | Protein kinase inhibitor and preparation method and medical application thereof | 甘李药业股份有限公司 | 2022-01-21 | — | — | CN | disclosed |
| US-20210371418-A1 | PROTEIN KINASE INHIBITORS, PREPARATION METHOD AND MEDICAL USE THEREOF | GAN & LEE PHARMACEUTICALS (CN) | 2021-12-02 | — | — | US | disclosed |
| US-11091476-B2 | Protein kinase inhibitors, preparation method and medical use thereof | GAN & LEE PHARMACEUTICALS | 2021-08-17 | — | — | US | disclosed |
| US-20200165239-A1 | PROTEIN KINASE INHIBITORS, PREPARATION METHOD AND MEDICAL USE THEREOF | GAN & LEE PHARMACEUTICALS (CN) | 2020-05-28 | — | — | US | disclosed |
| EP-3385262-A1 | PROTEIN KINASE INHIBITOR, PREPARATION METHOD AND MEDICAL USE THEREOF | Gan & Lee Pharmaceuticals (CN) | 2018-10-10 | — | — | EP | disclosed |
| EP-1868607-A4 | ISOQUNOLINE COMPOUNDS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2008-05-14 | — | — | EP | disclosed |
| EP-1868607-A2 | ISOQUNOLINE COMPOUNDS AND METHODS OF USE THEREOF | Inotek Pharmaceuticals Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| US-20060287313-A1 | Isoquinoline compounds and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2006-12-21 | — | — | US | disclosed |
| WO-2006093666-A2 | ISOQUNOLINE COMPOUNDS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2006-09-08 | — | — | WO | disclosed |
| US-6008347-A | N-substituted 2-azetidinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| US-5412092-A | N-substituted 2-azetidinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0627418-A1 | N-subtituted 2-azetidinones and processes for the production of N-unsubstituted 2-azetidinones therefrom | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-07 | — | — | EP | disclosed |
| US-4303792-A | N-substituted haloacyloxyacetamides herbicidal antidotes | STAUFFER CHEMICAL COMPANY (US) | 1981-12-01 | — | — | US | disclosed |