Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189528 | 0.84 | MAPT (0.42) | MAPTPKMALDH1A1GAAHSD17B10 | |
| SCHEMBL27550910 | 0.84 | MAPT (0.42) | MAPTPKMALDH1A1GAAHSD17B10 | |
| SCHEMBL1417951 | 0.84 | MAPT (0.42) | MAPTPKMALDH1A1GAAHSD17B10 | |
| Hydrochloric Acid SCHEMBL2920606 | 0.82 | MAPT (0.44) | MAPTPKMALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL4283062 | 0.82 | MAPT (0.44) | MAPTPKMALDH1A1HSD17B10 | |
| Acetic Acid SCHEMBL6729875 | 0.79 | MAPT (0.43) | MAPTPKMALDH1A1LMNAHSD17B10 | |
| SCHEMBL22122711 | 0.78 | SOAT1 (0.45) | MAPTPKMALDH1A1HSD17B10 | |
| SCHEMBL27677511 | 0.77 | PRCP (0.46) | MAPTPRCP | |
| Hydrochloric Acid SCHEMBL27638770 | 0.77 | SOAT1 (0.44) | MAPTPKMALDH1A1HSD17B10 | |
| SCHEMBL1951212 | 0.76 | PPM1B (0.37) | MAPTPKMPRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |