Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 20/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435357 | 0.93 | METAP2 (0.48) | METAP2 | |
| SCHEMBL10284181 | 0.93 | METAP2 (0.48) | METAP2 | |
| SCHEMBL10284188 | 0.89 | METAP2 (0.62) | METAP2 | |
| SCHEMBL461918 | 0.89 | METAP2 (0.47) | METAP2 | |
| SCHEMBL461919 | 0.89 | METAP2 (0.47) | METAP2 | |
| SCHEMBL10284179 | 0.89 | METAP2 (0.62) | METAP2 | |
| SCHEMBL436488 | 0.89 | METAP2 (0.60) | METAP2 | |
| SCHEMBL435674 | 0.89 | METAP2 (0.63) | METAP2 | |
| SCHEMBL10284262 | 0.89 | METAP2 (0.63) | METAP2 | |
| SCHEMBL434929 | 0.89 | METAP2 (0.62) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | disclosed |