Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953854 | 0.92 | TAAR1 (0.62) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL953241 | 0.88 | TAAR1 (0.63) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL4630512 | 0.83 | TAAR1 (0.57) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL4630242 | 0.82 | TAAR1 (0.54) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL953878 | 0.81 | TAAR1 (0.62) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL954135 | 0.80 | TAAR1 (0.60) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL954171 | 0.78 | TAAR1 (0.58) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL953613 | 0.77 | TAAR1 (0.63) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL955275 | 0.76 | TAAR1 (0.66) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL954953 | 0.75 | TAAR1 (0.60) | TAAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |