Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954171 | 0.97 | TAAR1 (0.58) | TAAR1HTR1AAOC3MAPK14MAPK1 | |
| SCHEMBL953854 | 0.89 | TAAR1 (0.62) | TAAR1HTR1AAOC3MAPTHPGD | |
| SCHEMBL954135 | 0.82 | TAAR1 (0.60) | TAAR1HTR1AKDM4EALDH1A1GAA | |
| SCHEMBL4630237 | 0.82 | TAAR1 (0.56) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL953878 | 0.80 | TAAR1 (0.62) | TAAR1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL954953 | 0.78 | TAAR1 (0.60) | TAAR1HTR1AL3MBTL1LMNAADRA2A | |
| SCHEMBL9414540 | 0.74 | TAAR1 (0.61) | TAAR1HTR1AMAPK14ALDH1A1GAA | |
| SCHEMBL955275 | 0.74 | TAAR1 (0.66) | TAAR1HTR1AADRA1AADRA2AADRA2B | |
| SCHEMBL4627741 | 0.73 | DPYD (0.36) | AOC3MAPK14MAPK1NTSR1KDM4E | |
| SCHEMBL953533 | 0.72 | F2RL1 (0.39) | MAPK14MAPK1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | claimed |