Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.33 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19812633 | 0.94 | GNAO1 (0.39) | TAAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL4630454 | 0.94 | GNAO1 (0.39) | TAAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL4630211 | 0.90 | TAAR1 (0.34) | TAAR1 | |
| SCHEMBL2701361 | 0.83 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL4659262 | 0.82 | — | — | |
| SCHEMBL4630985 | 0.81 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL4630216 | 0.79 | — | — | |
| SCHEMBL4629599 | 0.79 | — | — | |
| SCHEMBL4630109 | 0.79 | GBA1 (0.33) | MEN1KMT2A | |
| SCHEMBL9661914 | 0.78 | TAAR1 (0.41) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |