Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15092031 | 0.83 | HTT (0.61) | HTR2CEPHX1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL29175598 | 0.81 | HTT (0.50) | HTR2CHTTKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL28061413 | 0.81 | KMT2A (0.50) | HTR2CHTTKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL28167146 | 0.80 | ELANE (0.51) | HTTKMT2ASMN1; SMN2TDP1ELANE | |
| SCHEMBL5813373 | 0.80 | ELANE (0.51) | HTTKMT2ASMN1; SMN2TDP1ELANE | |
| SCHEMBL23390079 | 0.80 | HTR2C (0.68) | HTR2CEPHX1KMT2ASMN1; SMN2LIPE | |
| SCHEMBL17488206 | 0.80 | HTR2C (0.68) | HTR2CEPHX1KMT2ASMN1; SMN2LIPE | |
| SCHEMBL4630807 | 0.80 | HTR2C (0.61) | HTR2CEPHX1KMT2ASMN1; SMN2SSTR1 | |
| SCHEMBL27309277 | 0.79 | KMT2A (0.66) | EPHX1HTTKMT2ASMN1; SMN2TDP1 | |
| SCHEMBL23390539 | 0.78 | HTR2C (0.56) | HTR2CEPHX1TDP1SSTR1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |