Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10438269 | 0.97 | LMNA (0.65) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Citric Acid SCHEMBL28225959 | 0.95 | LMNA (0.64) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL21198846 | 0.95 | LMNA (0.59) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL28813672 | 0.95 | LMNA (0.62) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL28153403 | 0.95 | LMNA (0.62) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Citric Acid SCHEMBL8160075 | 0.95 | LMNA (0.62) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Citric Acid SCHEMBL8731625 | 0.95 | LMNA (0.62) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL20906377 | 0.95 | LMNA (0.62) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Citric Acid SCHEMBL17965941 | 0.95 | LMNA (0.62) | LMNACA4PDE4AUSP2SLCO1B1 | |
| Citric Acid SCHEMBL301966 | 0.95 | LMNA (0.62) | LMNACA4PDE4AUSP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1921933-A1 | PROCESSING FOR MAKING FILTER TOW | Celanese Acetate Limited (GB) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026131-A1 | PROCESSING FOR MAKING FILTER TOW | CELANESE ACETATE LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |