Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.60 |
| ▸ | PPARA | Q07869 | 12/20 | 0.60 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630851 | 0.76 | PPARG (0.63) | PPARGPPARACNR2 | |
| SCHEMBL977475 | 0.75 | PPARG (1.00) | PPARGPPARA | |
| SCHEMBL978747 | 0.75 | PPARG (1.00) | PPARGPPARA | |
| SCHEMBL1365900 | 0.74 | ALDH1A1 (0.56) | KCNA5 | |
| Tert-Butylamine SCHEMBL5308906 | 0.73 | PPARG (0.59) | PPARGPPARA | |
| SCHEMBL5312651 | 0.71 | PPARG (0.61) | PPARGPPARAMAPT | |
| SCHEMBL979749 | 0.70 | PPARG (1.00) | PPARGPPARA | |
| SCHEMBL979751 | 0.69 | PPARG (0.61) | PPARGPPARA | |
| SCHEMBL11864635 | 0.69 | PPARG (0.76) | PPARGPPARA | |
| SCHEMBL4630714 | 0.69 | PPARG (0.53) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517883-B8 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | ASTRAZENECA AB (SE) | 2008-05-21 | — | — | EP | claimed |
| EP-1517883-B1 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | ASTRAZENECA AB (SE) | 2008-02-13 | — | — | EP | claimed |
| EP-1517883-A1 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | AstraZeneca AB (SE) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000790-A1 | ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE | ASTRAZENECA AB (SE) | 2003-12-31 | — | — | WO | claimed |