Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347924 | 0.81 | AR (0.58) | ARALDH1A1ALOX5SMN1; SMN2NPSR1 | |
| SCHEMBL347529 | 0.77 | AR (0.49) | ARALDH1A1ALOX5HTTSMN1; SMN2 | |
| SCHEMBL348219 | 0.76 | AR (0.48) | ARALDH1A1ALOX5HTTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4090815 | 0.72 | ALDH1A1 (0.46) | ARALDH1A1ALOX5HTTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4092194 | 0.72 | AR (0.44) | ARALDH1A1ALOX5HTTSMN1; SMN2 | |
| SCHEMBL347552 | 0.71 | PTGDR2 (0.62) | ARALDH1A1HTTNPSR1KDM4E | |
| SCHEMBL4090820 | 0.70 | AR (0.42) | ARALDH1A1ALOX5HTTSMN1; SMN2 | |
| SCHEMBL4092197 | 0.69 | AR (0.41) | ARALDH1A1ALOX5HTTSMN1; SMN2 | |
| SCHEMBL4661535 | 0.69 | NPSR1 (0.46) | ALDH1A1HTTTDP1NPSR1MEN1 | |
| SCHEMBL347639 | 0.69 | EGFR (0.51) | ALDH1A1HTTSMN1; SMN2NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922312-A1 | THIAZOLE COMPOUNDS AND THEIR USE AS PGD2 ANTAGONISTS | Argenta Discovery Limited (GB) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007028999-A1 | THIAZOLE COMPOUNDS AND THEIR USE AS PGD2 ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2007-03-15 | — | — | WO | disclosed |