Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.42 |
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530249 | 0.84 | JAK2 (0.48) | JAK2JAK3MOKJAK1TYK2 | |
| SCHEMBL4525858 | 0.78 | JAK2 (0.41) | JAK2JAK3MOKPPARGPPARA | |
| SCHEMBL4522473 | 0.77 | ROCK2 (0.51) | MAPK1NPSR1ALDH1A1TSHR | |
| SCHEMBL4537056 | 0.77 | ROCK2 (0.51) | MAPK1NPSR1ALDH1A1TSHR | |
| SCHEMBL14338279 | 0.77 | JAK2 (0.56) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL14338306 | 0.76 | JAK2 (0.69) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4519208 | 0.73 | KMT2A (0.56) | MAPK1NPSR1ALDH1A1NPC1RAB9A | |
| SCHEMBL4524041 | 0.73 | KMT2A (0.56) | MAPK1NPSR1ALDH1A1NPC1RAB9A | |
| SCHEMBL14338278 | 0.69 | JAK2 (0.55) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL4375059 | 0.68 | JAK2 (0.79) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |