Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 9/20 | 0.57 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.49 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4632234 | 1.00 | CHRM3 (0.57) | CHRM3CHRM2CHRM1BLMPABPC1 | |
| Bromide SCHEMBL5993121 | 0.93 | CHRM3 (0.55) | CHRM3CHRM2CHRM1BLMPABPC1 | |
| Bromide SCHEMBL5993115 | 0.93 | CHRM3 (0.55) | CHRM3CHRM2CHRM1BLMPABPC1 | |
| Iodide SCHEMBL5108990 | 0.79 | CHRM3 (0.54) | CHRM3CHRM2CHRM1BLMPABPC1 | |
| Iodide SCHEMBL3820738 | 0.79 | CHRM3 (0.54) | CHRM3CHRM2CHRM1BLMPABPC1 | |
| Bromide SCHEMBL3824581 | 0.78 | CHRM3 (0.47) | CHRM3CHRM2CHRM1BLMPABPC1 | |
| Bromide SCHEMBL5103299 | 0.78 | CHRM3 (0.47) | CHRM3CHRM2CHRM1BLMPABPC1 | |
| SCHEMBL29706726 | 0.77 | CYP2D6 (0.46) | CYP1A2CYP2D6HIF1A | |
| Iodide SCHEMBL5102791 | 0.76 | CHRM3 (0.45) | CHRM3CHRM2CHRM1PABPC1 | |
| Iodide SCHEMBL5102786 | 0.76 | CHRM3 (0.45) | CHRM3CHRM2CHRM1PABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293531-A1 | Muscarinic Acetycholine Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2007-12-20 | — | — | US | claimed |
| EP-1781104-A4 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-05-21 | — | — | EP | disclosed |
| US-20070293531-A1 | Muscarinic Acetycholine Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2007-12-20 | — | — | US | disclosed |
| EP-1781104-A2 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006017768-A2 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293531-A1 | Muscarinic Acetycholine Receptor Antagonists | CHRM3, CHRNA7, CHRNA2 | CHRM3 1/4885CHRM2 7/4885CHRM1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.