Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL3483407 | 0.96 | — | — | |
| SCHEMBL7064730 | 0.93 | CA4 (0.47) | FFAR3CA4TDP1ALDH1A1HDAC3 | |
| SCHEMBL1332396 | 0.93 | — | — | |
| SCHEMBL9342808 | 0.93 | FFAR3 (0.41) | FFAR3CA4TDP1ALDH1A1HDAC3 | |
| SCHEMBL3851900 | 0.93 | — | — | |
| Pyruvate SCHEMBL31434671 | 0.80 | CA4 (0.50) | FFAR3CA4TDP1ALDH1A1HDAC3 | |
| Propionic Acid SCHEMBL29493216 | 0.77 | FFAR3 (0.53) | FFAR3CA4TDP1ALDH1A1HDAC3 | |
| Propionic Acid SCHEMBL106190 | 0.77 | — | — | |
| Propionic Acid SCHEMBL4896693 | 0.77 | FFAR3 (0.53) | FFAR3CA4TDP1ALDH1A1HDAC3 | |
| Propionic Acid SCHEMBL240639 | 0.77 | FFAR3 (0.53) | FFAR3CA4TDP1ALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830828-A4 | USE OF METHYL PYRUVATE TO INCREASE CELLULAR ENERGY PRODUCTION DOWNSTREAM OF GLYCOLYSIS | ANTOSH & MEDURI HOLDING CORP (US) | 2008-07-02 | — | — | EP | claimed |
| EP-1781108-A4 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2008-06-04 | — | — | EP | claimed |
| EP-1830828-A2 | USE OF METHYL PYRUVATE TO INCREASE CELLULAR ENERGY PRODUCTION DOWNSTREAM OF GLYCOLYSIS | Antosh & Meduri Holding Corporation (US) | 2007-09-12 | — | — | EP | claimed |
| EP-1796460-A2 | USE OF METHYL PYRUVATE OR METHYL PYRUVIC ACID FOR THE TREATMENT OF DISEASES OF THE NERVOUS SYSTEM AND FOR PROTECTING A HUMAN CENTRAL NERVOUS SYSTEM AGAINST NEURONAL DEGENERATION CAUSED BY DEFECTIVE INTRACELLULAR ENERGY PRODUCTION | Antosh, Stanley C. (US) | 2007-06-20 | — | — | EP | claimed |
| EP-1781108-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | Antosh, Stanley C. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006055764-A2 | USE OF METHYL PYRUVATE TO INCREASE CELLULAR ENERGY PRODUCTION DOWNSTREAM OF GLYCOLYSIS | ANTOSH STANLEY C (US) | 2006-05-26 | — | — | WO | claimed |
| US-20060111442-A1 | Use of methyl pyruvate to increase cellular energy production downstream of glycolysis for the PARP-1 ablation of HIV without necrotic cell death caused by continuous, chronic PARP-1 activation through the concomitant depletion of ATP and NAD. | Antosh, Mr. Stanley (US) | 2006-05-25 | — | — | US | claimed |
| WO-2006028948-A2 | USE OF METHYL PYRUVATE OR METHYL PYRUVIC ACID FOR THE TREATMENT OF DISEASES OF THE NERVOUS SYSTEM AND FOR PROTECTING A HUMAN CENTRAL NERVOUS SYSTEM AGAINST NEURONAL DEGENERATION CAUSED BY DEFECTIVE INTRACELLULAR ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2006-03-16 | — | — | WO | claimed |
| US-20060052448-A1 | Use of methyl pyruvate or methyl pyruvic acid for the treatment of diseases of the nervous system and for protecting a human central nervous system against neuronal degeneration caused by defective intracellular energy production. | Antosh, Mr. Stanley (US) | 2006-03-09 | — | — | US | claimed |
| WO-2006017590-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF REDUCING WEIGHT GAIN IN MAMMALS | ANTOSH STANLEY C (US) | 2006-02-16 | — | — | WO | claimed |
| WO-2006015232-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2006-02-09 | — | — | WO | claimed |
| US-20060025475-A1 | Use of methyl pyruvate for the purpose of increasing muscle energy production. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | claimed |
| US-20060025476-A1 | Use of methyl pyruvate for the purpose of reducing weight gain in mammals. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | claimed |
| EP-1781108-A4 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2006017590-A3 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF REDUCING WEIGHT GAIN IN MAMMALS | ANTOSH STANLEY C (US) | 2007-08-16 | — | — | WO | disclosed |
| EP-1781108-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | Antosh, Stanley C. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006017590-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF REDUCING WEIGHT GAIN IN MAMMALS | ANTOSH STANLEY C (US) | 2006-02-16 | — | — | WO | disclosed |
| WO-2006015232-A2 | USE OF METHYL PYRUVATE FOR THE PURPOSE OF INCREASING MUSCLE ENERGY PRODUCTION | ANTOSH STANLEY C (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060025475-A1 | Use of methyl pyruvate for the purpose of increasing muscle energy production. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | disclosed |
| US-20060025476-A1 | Use of methyl pyruvate for the purpose of reducing weight gain in mammals. | Antosh, Stanley (US) | 2006-02-02 | — | — | US | disclosed |