Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847226 | 0.70 | MAPK1 (0.52) | L3MBTL1ALDH1A1LMNA | |
| SCHEMBL27962807 | 0.69 | EPHX1 (0.43) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL1971684 | 0.68 | SMN1; SMN2 (0.44) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL20495571 | 0.67 | MAPK1 (0.39) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL1681540 | 0.66 | — | — | |
| SCHEMBL16824229 | 0.65 | EPHX1 (0.59) | SMN1; SMN2HPGDCYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL590532 | 0.65 | EPHX1 (0.59) | RAB9AHPGDALDH1A1TSHRNPSR1 | |
| SCHEMBL5340890 | 0.65 | ESR1 (0.56) | RAB9ANPC1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL1383077 | 0.65 | SMN1; SMN2 (0.50) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL7841197 | 0.65 | SMN1; SMN2 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924563-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1-INHIBITOR-DIABETES-TYPE 2-1 | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025892-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1-INHIBITOR-DIABETES-TYPE 2-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |