Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383077 | 0.96 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL3010245 | 0.95 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL8589909 | 0.90 | EPHX1 (0.56) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL8590406 | 0.88 | EPHX1 (0.54) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL7194159 | 0.86 | EPHX1 (0.59) | SMN1; SMN2EPHX1ACHEGAA | |
| SCHEMBL28783627 | 0.85 | GNAI3 (0.55) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL6381523 | 0.83 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL7009651 | 0.82 | EPHX1 (0.40) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL6582896 | 0.82 | MAPT (0.47) | SMN1; SMN2NPC1MAPTRAB9ATP53 | |
| SCHEMBL5747211 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1MAPTRAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102762-A2 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER INC. (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008013-A2 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-02-17 | — | — | WO | disclosed |